6-Thioguanine

Manufacturer supply 6-Thioguanine 154-42-7 with sufficient stock and high standard We provide high quality 6-Thioguanine (CAS 154-42-7), at a very affordable prices to our customers.

1.What is the 6-Thioguanine ?

6-Thioguanine (NSC 752, Thioguanine, 2-Amino-6-purinethiol), is an antineoplastic metabolic antagonist that inhibits DNA synthesis by being metabolically converted to 6-thioGMP. This inhibits purine biosynthesis at multiple steps, and may be phosphorylated and incorporated into DNA. In humans, it causes bone marrow depression and gastrointestinal toxicity. Due to safety problems it is currently less used as an antineoplastic agent but has some use as therapy for ulcerative colitis.

6-Thioguanine is a purine analogue structurally related to 6-mercaptopurine and azathioprine. Thioguanine interferes with several enzymes required for de novo purine synthesis, and its metabolites are incorporated into DNA and RNA, further impeding nucleic acid synthesis. The mechanism of action of thioguanine in psoriasis is not clearly understood; it has been hypothesized to affect the proliferation and trafficking of lymphocytes as well as the proliferation of keratinocytes.

6-Thioguanine acts as an antineoplastic and purine antimetabolite. It is also useful as an inhibition of stimulated expression of TNF-related apoptosis-inducing ligand (TRAIL) protein. It is involved in the treatment of acute leukemias and Psoriasis. Further, it is used for the treatment of ulcerative colitis and autoimmune diseases.

2.What is the CAS number for 6-Thioguanine ?

The CAS number of 6-Thioguanine is 154-42-7.

More information of 6-Thioguanine 154-42-7 are:

3.What is the molecular formula of 6-Thioguanine ?

The chemical formula of?6-Thioguanine is C5H5N5S which containing 5 Carbon atoms,5 Hydrogen atoms,5 Nitrogen atoms and 1 Sulfur atoms,and the molecular weight, and the molecular weight of 6-Thioguanine is 167.194

4.What is 6-Thioguanine(154-42-7)used for?

6-Thioguanine (NSC 752, Thioguanine, 2-Amino-6-purinethiol), is an antineoplastic metabolic antagonist that inhibits DNA synthesis by being metabolically converted to 6-thioGMP. This inhibits purine biosynthesis at multiple steps, and may be phosphorylated and incorporated into DNA. In humans, it causes bone marrow depression and gastrointestinal toxicity. Due to safety problems it is currently less used as an antineoplastic agent but has some use as therapy for ulcerative colitis.

InChI:InChI=1/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)/p-1

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5.Manufacturer supply 6-Thioguanine 154-42-7 with sufficient stock and high standard

Beijing ZhongDaXinHe Chemical Product Co.,Ltd is a quality supplier of 6-Thioguanine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 6-Thioguanine 154-42-7.